Antepartum and genetic testing codes
The short answer
Antepartum surveillance like the non-stress test (59025) and biophysical profile bills separately from the global package when medically indicated. Prenatal genetic testing uses lab codes such as 81420 for NIPT, and payer prior-authorization rules drive most denials here.
Source: NCCISource: CMS MPFS 2026
NIPT Billing from the Practice Side The lab bills the test; the practice's order, prior auth, and diagnosis code decide whether it pays. NIPT Coding and Coverage for Carrier Screening Single-gene codes get covered; the 81443 panel splits payers into tiers, and the lab's code choice drives the patient bill. 81443 + Rh Immune Globulin Billing Two lines every time: product 90384 plus admin 96372, and the 28-week dose bills outside the global. 90384 + 96372 Amniocentesis, Diagnostic CPT 59000 code description in plain language: diagnostic amniocentesis. Billing guidance code 76946 separately, global-package status, and common denials. 59000 Fetal Non-Stress Test (NST) CPT 59025 code description in plain language: the fetal non-stress test (NST). When an NST is separately billable, documentation requirements, TC/26 splits, 2026 Medicare rates, and common denials. 59025 NIPT Cell-Free DNA Aneuploidy Screening CPT 81420 code description in plain language: NIPT, the cell-free DNA screen for fetal aneuploidy. Who bills it, prior auth, Z-code rules, and denials. 81420 Expanded Carrier Screening Panel CPT 81443 code description in plain language: the expanded carrier screening panel (15+ genes). Panel vs single-gene coding, coverage tiers, and the patient bill. 81443 Assay-Specific Cell-Free DNA Screening CPT 81507 code description in plain language: the assay-specific cell-free DNA screen some labs bill instead of 81420, and what it changes for the practice. 81507